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Joseph F Costello Selected Research

GA-Binding Protein Transcription Factor

12/2022TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo.
5/2015Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.

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Joseph F Costello Research Topics

Disease

44Neoplasms (Cancer)
11/2022 - 06/2002
27Glioma (Gliomas)
01/2022 - 05/2005
19Glioblastoma (Glioblastoma Multiforme)
12/2022 - 09/2006
10Carcinogenesis
12/2022 - 06/2002
7Oligodendroglioma
01/2022 - 06/2008
6Meningioma (Meningiomas)
01/2022 - 06/2005
5Astrocytoma (Pilocytic Astrocytoma)
01/2022 - 06/2008
5Brain Neoplasms (Brain Tumor)
01/2021 - 05/2005
2Inflammation (Inflammations)
01/2019 - 07/2008
2Sarcoma (Soft Tissue Sarcoma)
11/2017 - 04/2017
2Disease Progression
01/2017 - 09/2011
2Retinoblastoma (Glioblastoma, Retinal)
01/2014 - 06/2008
2Colonic Neoplasms (Colon Cancer)
10/2008 - 09/2007
1Neuroblastoma
01/2022
1Hepatocellular Carcinoma (Hepatoma)
01/2022
1Melanoma (Melanoma, Malignant)
01/2022
1Neoplasm Metastasis (Metastasis)
01/2020
1Ependymoma
01/2020
1Prostatic Neoplasms (Prostate Cancer)
01/2020
1Li-Fraumeni Syndrome
01/2018
1Microsatellite Instability
11/2017
1Hypersensitivity (Allergy)
02/2015
1Hypoxia (Hypoxemia)
02/2015
1Triple Negative Breast Neoplasms
04/2012
1Gliosarcoma
12/2011
1Lung Neoplasms (Lung Cancer)
04/2011

Drug/Important Bio-Agent (IBA)

12Temozolomide (Temodar)FDA LinkGeneric
11/2021 - 04/2011
10DNA (Deoxyribonucleic Acid)IBA
01/2020 - 06/2002
8Telomerase (Telomerase Reverse Transcriptase)IBA
12/2022 - 05/2014
7Biomarkers (Surrogate Marker)IBA
11/2022 - 01/2020
7Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2005
7Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
02/2021 - 06/2016
6Biological ProductsIBA
01/2022 - 04/2007
4MicroRNAs (MicroRNA)IBA
01/2021 - 06/2008
3Pyruvic Acid (Pyruvate)IBA
01/2022 - 11/2020
3Pharmaceutical PreparationsIBA
02/2021 - 01/2013
3alpha-hydroxyglutarateIBA
02/2021 - 11/2016
3NucleotidesIBA
01/2020 - 04/2007
3hydrogen sulfite (bisulfite)IBA
01/2020 - 05/2005
3Histones (Histone)IBA
11/2016 - 07/2009
2GA-Binding Protein Transcription FactorIBA
12/2022 - 05/2015
2Transcription Factors (Transcription Factor)IBA
11/2022 - 12/2021
2Lactic Acid (Lactate)FDA LinkGeneric
01/2022 - 01/2021
2Doxycycline (Periostat)FDA LinkGeneric
01/2022 - 01/2021
2Glucose (Dextrose)FDA LinkGeneric
01/2021 - 02/2015
2Long Noncoding RNAIBA
01/2021 - 03/2018
2RNA (Ribonucleic Acid)IBA
01/2020 - 04/2017
2Alkylating AgentsIBA
12/2019 - 04/2011
2TOR Serine-Threonine KinasesIBA
12/2017 - 01/2014
25-Methylcytosine (5 Methylcytosine)IBA
01/2013 - 09/2006
2Phosphotransferases (Kinase)IBA
08/2009 - 06/2007
1Neurofibromin 2 (Merlin)IBA
01/2022
1Cytostatic AgentsIBA
01/2022
1Phospho-Specific AntibodiesIBA
01/2022
1DeuteriumIBA
01/2022
1NAD (NADH)IBA
01/2022
1Alanine (L-Alanine)FDA Link
01/2021
1Glutamic Acid (Glutamate)FDA Link
11/2020
1Glutamine (L-Glutamine)FDA Link
11/2020
1LipidsIBA
01/2019
1CholesterolIBA
01/2019
12,2',4,4'-tetrabromodiphenyl etherIBA
01/2019
1Protein Isoforms (Isoforms)IBA
10/2018
1isocitric acid (isocitrate)IBA
01/2018
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
12/2017
1MTOR InhibitorsIBA
12/2017
1EverolimusFDA Link
12/2017
1DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
11/2017
1CarcinogensIBA
11/2017
1MutagensIBA
11/2017
1ChemokinesIBA
04/2017
1VaccinesIBA
04/2017
1AgarIBA
11/2016
1Deoxyribonuclease I (Nickase)IBA
02/2015
1Hypoxia-Inducible Factor 1IBA
02/2015
1Mitochondrial Proteins (Mitochondrial Protein)IBA
02/2015
1Oxygen (Dioxygen)IBA
02/2015
1MethyltransferasesIBA
02/2015
1ChromatinIBA
11/2014
1HeterochromatinIBA
11/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2014
1ErbB Receptors (EGF Receptor)IBA
07/2014
1Bevacizumab (Avastin)FDA Link
07/2014
1Erlotinib Hydrochloride (CP 358,774)FDA Link
07/2014
1histone H3 trimethyl Lys4IBA
05/2014
1Lysine (L-Lysine)FDA Link
05/2014
1N,N'-bis(4-azidobenzoyl)cystineIBA
01/2014
1Histone MethyltransferasesIBA
06/2013
15-hydroxymethylcytosineIBA
01/2013
1Protein Kinases (Protein Kinase)IBA
01/2013
1Progesterone Receptors (Progesterone Receptor)IBA
04/2012
1enzastaurinIBA
12/2011
1Messenger RNA (mRNA)IBA
09/2011
1ORALIT (ORS)IBA
04/2011

Therapy/Procedure

20Therapeutics
01/2022 - 01/2003
5Drug Therapy (Chemotherapy)
11/2021 - 06/2008
4Radiotherapy
11/2021 - 12/2011
2Immunotherapy
01/2021 - 04/2017
1Castration
01/2020
1Heterologous Transplantation (Xenotransplantation)
10/2018